Here’s what happens when patients go

Unprotected From infection Due to lowered Neutrophil Counts

It’s well known that neutrophils are a patient’s first line of defense against infection.1

Chemotherapy suppresses the hematopoietic system. it also:


the production of critical neutrophils, greatly lowering their numbers1


a patient’s immune defenses and increases infections1


bacterial proliferation and invasion1


chemotherapy-induced neutropenia (CIN)1

Take a closer look at neutropenia

And see why myelosuppression, including CIN, is the number one reason chemotherapy regimens are forced to be changed.2

Every day may make a difference for a patient on cytotoxic chemotherapy. Because of the significant risk of sepsis and potentially life-threatening events, CIN needs to be monitored regularly to optimize care and outcomes for patients.3

Learn more about the Neutropenia Vulnerability Gap

Expert Perspectives in CIN

Video Transcript

Dr. Lyman: It’s also important that patients be educated about the risk of neutropenia and the importance of being cautious, avoiding opportunities that might put them at risk for infection, family members or friends with infection, much of the same thing we’re going through now with COVID-19 is to avoid exposure to patients who might already have, in this case, the bigger problem being a bacterial infection that might pose a risk when the patient becomes neutropenic.


When a patient’s absolute neutrophil count (ANC) decreases and approaches 1.0 or below, they run the risk of encountering life-threatening events, including:

Who’s at the greatest risk for Cin?


  1. Crawford J, Dale DC, Lyman GH. Chemotherapy-induced neutropenia: risks, consequences, and new directions for its management. Cancer. 2004;100(2):228-237.
  2. Lyman GH. Management of chemotherapy-induced neutropenia with colony-stimulating factors. Eur Oncol. 2008;4(2):13-17.
  3. Gupta A, Abbasi B, Gupta S. Management of chemotherapy induced neutropenia—an unmet clinical need. Am J Biomed Sci & Res. 2019;4(5):313-318.
  • Mechanism of disease
  • Risk Factors
  • Disease Madnitude
  • Disrupted Outcomes
  • Neutropenia Vulnerability Gap
  • Cost Resource Burden
  • Need for Innovation
  • Resources